Travel requirements to enter the Czech Republic are constantly evolving. It is necessary to check them regularly.
Please find below general information regarding entry into the territory of the Czech Republic:
Currently citizens of non-European countries (third countries*) who are not vaccinated or who are vaccinated by vaccines not recognized by the Czech Republic must get the special Confirmation (Permission) to enter from the National Sport Agency (the application for this you will find in the Entries).
Information about recognized vaccines you will find here https://koronavirus.mzcr.cz/en/recognition-of-vaccination-certificates-from-other-countries/
* A third-country national is a citizen of a state that is not member of the EU nor a citizen of Iceland, Lichtenstein, Norway or Switzerland.
PCR test to re-enter home country - In case you need PCR for return, the easiest way is, to have it done at the airport immediately upon your arrival to Prague see link below https://www.prg.aero/en/testing-covid-19
In case of any questions contact firstname.lastname@example.org